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cerebellar atrophy dilantin treatment

131 patients with epilepsy and phenytoin exposure.


The majority of the patients were severely retarded, with 83% having an intelligence quotient of less than 35.


No controls were employed.


The authors thought that cerebellar atrophy as diagnosed with pneumoencephalography

correlated with a history of phenytoin intoxication and serum phenytoin levels.


As in the previously mentioned study, the issue of possible preexistent congenital

cerebellar pathology is not addressed.


At most,one could only conclude that phenytoin may play a role with respect to cerebellar atrophy in brain-damaged individuals.


In the only investigation that we know of in

which modern neuroimaging techniques were used,

Ballenger compared the computed tomographic

scans of 70 patients with seizures with those of a control group and failed to demonstrate cerebellar atrophy within the seizure group; 84% of the seizure

group had had significant phenytoin exposure.


Detailsof the epilepsy group are not available. Furthermore, mild cerebellar atrophy may have been missed on computed tomographic scans....

Dilantin causes Cerebellar Atrophy

Brain Atrophy Cerebellum

Cerebellar Atroph Volume Loss

Ataxia Cerebellar Atrophy

Cerebellar Shrinking

Dilantin cerebellar atrophy

Cerebellar degeneration

Cerebellar atrophy symptoms Cerebral cortical atrophy