Patients have develop marked cerebellar atrophy following episodes of acute and severe phenytoin intoxication.
Phenytoin can accumulate in the cerebellar cortex over long periods of time which can cause atrophy of the cerebellum.
Cerebellar atrophy related to phenytoin use. Cerebellar Atrophy is a serious progressive condition that the cerebellum shrinks to a much smaller size than the normal one.
Cerebellar atrophy is frequently associated with long-term use of phenytoin. Although duration of epilepsy may have an influence in the cerebellar atrophy, clearly the epilespy episodes are less important than the time of exposure to phenytoin.
Signs you may have Cerebellar atrophy are degeneration of the cerebellum, a section of the brain responsible for balance, voluntary muscle movements, and posture.
The cerebellum is responsible for relaying messages about posture, equilibrium, movement and fine motor skills such as writing or catching a ball.
Scientific evidence indicates that phenytoin can directly cause cerebellar degeneration.
Medical research literature identifies patients exposed to phenytoin have been identified with associated cerebellar atrophy.
MRI shows Progressive cerebellar atrophy
wishful thinking, cognitive decline, memory impairment, personality change as well as paralysis and seizures. Focal cerebellar atrophy often leads to character change, tremor and loss of function, such as slurred speech and ataxic movement.
Developing Stages of Cerebellar Atrophy
Three developing stages of cerebellar atrophy:
At the initial stage of cerebellar atrophy, the patients may have the following symptoms:
1. Dizziness while walking
2. Inflexibility of movements, difficulty lifting objects and loss of smoothness of movements
3. Incoordination of the legs in climbing stairs, stiffness of muscles, inability of exactly accomplishing certain movements, such as jogging, climbing mountains, etc
4. Swinging of the body at standing position
5. Difficulty of moving the eyes and inability of rapidly moving the directions
6. Difficulty of judging distance, such as unable to hit the table tennis
Middle stage, symptoms of which including the follows:
1. Aggravated heaviness and incoordination of four limbs and muscles, and loss of coordination
2. Inability to control body postures and gait; swinging of body postures, inability maintaining balance, inability jogging, difficulty climbing stairs, etc
3. Slurring of speech, difficulty writing, drinking or eating, choking
Advanced stage, symptoms of which including the follows:
1. Unclearness or loss of speech; written words hard to be understood or distinguished, swallowing difficulty
2. Inability standing up or sitting; staying on bed and unable to look after oneself
3. Impairment of intelligence