Risk of Cerebellar Atrophy

Maria J. Borja

Phenytoin has the capability to limit the hyperexcitability of tissues by selectively blocking the neurons that fire at a high frequency.

Cerebellar atrophy is attributed to loss of Purkinje cells, which may be due to toxic effects of phenytoin and/or .seizure activities..

Cerebral atrophy and skull thickening due to chronic phenytoin therapy.

Chronic Phenytoin therapy

Chow KM, Szeto CC.CMAJ. 2007 Jan 30;176(3):321-3. doi: 10.1503/cmaj.061171.PMID: 17261827 

Imaging Features of Therapeutic Drug–induced.

pubs.rsna.org› doi › Dec 30, 2012 -However, a rise in therapeutic drug use with increasing age mean that Phenytoin therapy has been shown to induce calvarial thickening …by HS Sidhu – ‎2012