Maria J. Borja
Phenytoin has the capability to limit the hyperexcitability of tissues by selectively blocking the neurons that fire at a high frequency.
Cerebellar atrophy is attributed to loss of Purkinje cells, which may be due to toxic effects of phenytoin and/or .seizure activities..
Chronic Phenytoin therapy
Chow KM, Szeto CC.CMAJ. 2007 Jan 30;176(3):321-3. doi: 10.1503/cmaj.061171.PMID: 17261827
Imaging Features of Therapeutic Drug–induced.
pubs.rsna.org› doi › Dec 30, 2012 -However, a rise in therapeutic drug use with increasing age mean that Phenytoin therapy has been shown to induce calvarial thickening …by HS Sidhu – 2012